How are psychedelic trials and new models of psychosis care revaluing psychotic experiences by engaging them therapeutically, and what can we learn by bringing these worlds into dialogue? Funded by a Wellcome Trust Early-Career Award (2026-2031), Madness in Medicine (MadMed) is a new study bridging divided research on psychedelics and psychosis to discover how psychotic-like experiences are made therapeutic in everyday clinical practice and generate new insight into the changing therapeutic cultures of mental health care. Through community-engaged clinical ethnography with clinicians and experts by experience in South London, this research will provide new insight into how therapeutic value, safety, and efficacy are changing in the context of the burgeoning ‘psychedelic renaissance’ and the ongoing global mental health crisis.